Is there a role for TNFα antagonists in the treatment of SSc ?
نویسندگان
چکیده
To obtain experiences and expert opinion on treatment of SSc patients with TNF-α
منابع مشابه
Successful treatment of infliximab in a patient with scleroderma: a case report
RATIONALE Systemic Scleroderma (SSc) is a rare connective tissue disease clinically characterized by cutaneous sclerosis and variable systemic involvement. No drug is currently available to effectively reverse the fibrotic process in SSc. Previous reports have suggested that the tumor necrosis factor (TNF) antagonists could be useful for the treatment of fibrotic disorders. However, TNFα has lo...
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Systemic sclerosis (SSc) is a chronic autoimmune disease, featuring fibrosis in multiple organs. The serum from SSc patients contain inflammatory mediators, contributing to SSc pathogenesis and could be used to develop cell culture models. Here, we compared the fibrotic effects of serum samples from SSc patients with TGFβ1 on human dermal fibroblasts (HDFs). HDF cells were cultured in four diff...
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تاریخ انتشار 2017